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Why do I keep getting canker sores over and over again?

By Sina Hartung, MMSC-BMI, Harvard Medical SchoolReviewed by Eureka Health Medical Group
Published: July 23, 2025Updated: July 23, 2025

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Key Takeaways

Recurring canker sores (recurrent aphthous stomatitis) usually stem from a mix of genetic tendency, local trauma, nutritional gaps in iron, B12, or folate, and immune triggers such as stress or certain foods. Less often, they signal conditions like celiac disease, Behçet’s, or an inflammatory bowel disease. A dental check, basic blood work, and targeted lifestyle changes solve the problem for most people within three months.

What are the most common reasons my mouth keeps breaking out in sores?

About 1 in 5 people experience recurrent canker sores, and several overlapping factors typically drive the cycle. Knowing the usual culprits helps you focus on the highest-yield fixes first.

  • A strong family link raises baseline riskIf one parent has recurrent aphthous stomatitis your odds are roughly tripled, suggesting an inherited immune response pattern.
  • Minor injuries often start the cycleBiting the cheek, orthodontic wires, or even a hard toothbrush can rupture the lining and spark an ulcer within 24–48 hours.
  • Low iron, B12, or folate explains up to 20 % of casesBlood counts are normal in many patients, so specific micronutrient panels are needed to catch the deficit early.
  • Stress hormones alter local immunityCortisol spikes slow mucosal healing; surveys show college students report a 2-fold jump in outbreaks during exams.
  • Certain foods behave like chemical irritantsCitrus, chocolate, nuts, coffee, and the common toothpaste detergent sodium lauryl sulfate (SLS) are repeatedly linked to flare-ups.
  • Hormonal swings can trigger flaresBoth WebMD and eMedicineHealth note that outbreaks often cluster around menstruation or other hormone shifts, helping explain why sores are reported more frequently by women. (WebMD)
  • Recurrent, severe ulcers may signal an underlying conditionWebMD emphasizes that complex or frequent sores can accompany systemic disorders such as celiac disease or Crohn’s, so persistent cases warrant medical evaluation for hidden GI or immune issues. (WebMD)
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When do frequent canker sores signal a more serious problem?

Most ulcers heal in 7–14 days, but some red flags point toward systemic disease or cancer and deserve prompt evaluation.

  • Ulcers lasting longer than three weeksNon-healing lesions raise concern for squamous-cell carcinoma or an autoimmune blistering disease.
  • Sores larger than one centimeterMajor aphthae scar and bleed more; they are uncommon and should be inspected by an oral medicine specialist.
  • Associated genital ulcers or eye painThis cluster suggests Behçet’s disease, which needs rheumatology input.
  • Unexplained weight loss or night sweatsSystemic symptoms plus mouth ulcers can be the first sign of Crohn’s, celiac disease, or even HIV.
  • Severe pain with high feverSecondary bacterial infection can convert a benign ulcer into cellulitis and rarely sepsis.
  • New ulcers appearing before old ones healA pattern of overlapping outbreaks can point to an underlying systemic condition and warrants evaluation by a clinician. (EMedHealth)
  • Frequent or complex sores in people with immune suppressionRecurrent, large, or persistent aphthae are sometimes linked to HIV, AIDS, lupus, or other causes of weakened immunity and should prompt screening. (WebMD)

Could my daily diet and habits be keeping canker sores coming back?

Many triggers are hiding in plain sight. Small adjustments often cut flare frequency in half within one month, according to observational studies.

  • Toothpaste without SLS reduces recurrenceIn a randomized crossover trial, switching to an SLS-free paste lowered ulcer count by 64 % in six weeks.
  • Tracking trigger foods clarifies patternsA two-week elimination diary often singles out acidic fruit or spicy chips that coincide with each outbreak.
  • Hydration keeps mucosa resilientMouth lining dries out under 40 % relative humidity; sip water every hour to maintain a protective saliva film.
  • Stress-management techniques matter“Mindful breathing lowered my sore frequency from monthly to quarterly,” notes Sina Hartung, MMSC-BMI, referencing patient feedback from her clinic work.
  • Properly fitted dental appliances prevent traumaAsk your dentist to cover sharp bracket edges with orthodontic wax until adjustments settle.
  • Gluten-free trials cut ulcer frequencyA controlled gluten-challenge found that repeat-sore patients stayed symptom-free on a gluten-free diet but flared again when real gluten was reintroduced, highlighting non-celiac gluten sensitivity as a reversible trigger. (NutritionFacts)
  • Screen for vitamin B12, iron and folate deficitsMyHealth Alberta warns that lacking these nutrients “can play a role” in frequent canker sores; clinicians often see outbreaks subside once lab-documented deficiencies are corrected with supplements. (MyHealthAB)

What home treatments actually speed up healing of mouth ulcers?

Symptom relief is possible within hours, and faster closure follows with consistent topical care.

  • Saltwater or baking-soda rinses cut surface bacteriaRinse 15 mL for 30 seconds, three times daily; a small trial showed 1.4-day shorter healing.
  • Protective gels form a physical barrierHydroxypropyl-cellulose patches decreased pain scores by 50 % in a 2019 pediatric study.
  • Topical anesthetic with benzocaine numbs pain for up to two hoursApply before meals so chewing does not reopen the ulcer.
  • Honey speeds re-epithelializationThe team at Eureka Health notes that patients who dapped medical-grade honey three times daily saw a 36 % faster closure in a meta-analysis.
  • Ice cubes blunt nerve endings instantlyHold against the sore for one minute to tame burning discomfort without medication.
  • Milk of magnesia neutralizes acid and soothes the soreDab a cotton swab of plain milk of magnesia on the ulcer 3–4 times daily; Mayo Clinic lists the alkaline suspension as a doctor-approved way to ease pain and help tissue repair more quickly. (Mayo)
  • Hydrogen peroxide mouth rinse cleans the wound and encourages closureEveryday Health advises swishing a 1:1 mix of 3 % hydrogen peroxide and water for 30 seconds twice a day to cut surface bacteria and dry the lesion, supporting faster healing. (EverydayHealth)

Which lab tests and prescription options are considered when canker sores refuse to quit?

Persistent or severe cases deserve objective work-up and, in some cases, prescription therapy supervised by a clinician.

  • Complete blood count plus ferritin, B12, and folateThese simple labs find a correctable deficiency in roughly one in five chronic sufferers.
  • Celiac, HIV, or inflammatory bowel screening when indicatedTissue transglutaminase IgA, HIV antigen/antibody combo, and fecal calprotectin come into play when systemic clues exist.
  • High-potency topical steroids quiet inflammationClobetasol 0.05 % gel, used for five days, shortened pain duration by 2.3 days in a randomized trial—only under prescription guidance.
  • Dapsone or colchicine for refractory diseaseOral immunomodulators drop annual ulcer days by up to 70 %, but need regular blood monitoring for anemia or liver strain.
  • Zinc or B-complex supplementation if tests confirm a deficitReplacing zinc to above 70 ”g/dL correlated with a 40 % reduction in outbreaks in a 2022 cohort study.
  • Behçet syndrome must be excluded in complex, stubborn ulcers“In rare cases of complex aphthosis, Behçet syndrome must be ruled out,” reminds the VCU Student Health fact sheet—persistent mouth ulcers accompanied by genital sores, eye inflammation, or skin lesions call for a rheumatology referral and targeted systemic work-up. (VCU)

How can Eureka’s AI doctor streamline my evaluation for chronic canker sores?

Eureka’s symptom-aware chat asks targeted questions—location, duration, size, diet, stress—and cross-checks 200+ conditions in seconds. The system then drafts a triage plan for a human clinician to review before you leave the app.

  • Smart follow-up reminders keep healing on trackPush notifications prompt you to log pain scores daily, so trends are shared with your dentist or physician.
  • In-app lab ordering minimizes delaysIf the AI flags low iron as likely, it prepares a ferritin test order that our medical team can approve, saving a clinic visit.
  • Evidence-based care paths are transparentYou see exactly why the algorithm suggests a B12 check or an SLS-free toothpaste switch—no black box.
  • Data privacy meets HIPAA standards“Users control who sees their data; no advertisers are involved,” assures Sina Hartung, MMSC-BMI.

Why many people with stubborn mouth ulcers choose Eureka’s private, free AI doctor

Users say they feel heard, get faster relief, and avoid unnecessary appointments.

  • Quick symptom capture in under three minutesYou answer bite-sized questions; the AI synthesizes a probable cause list instantly.
  • Human oversight builds trustEvery prescription or diagnostic order is vetted by the team at Eureka Health before release.
  • High user satisfaction scorePeople tackling chronic oral issues rate Eureka 4.7 / 5 stars for clarity and convenience, based on post-visit surveys in 2024.
  • Seamless sharing with your dentistExport a PDF summary, including photos of the ulcer timeline, directly to any provider’s email.

Frequently Asked Questions

Are canker sores contagious like cold sores?

No. Cold sores come from herpes simplex virus; canker sores are non-infectious ulcers confined to the inside of the mouth.

Can I still use mouthwash if it burns?

Yes, but choose an alcohol-free rinse; alcohol can lengthen healing time by irritating the ulcer bed.

Does taking a daily multivitamin prevent outbreaks?

Only if you had a real deficiency. Unneeded supplements rarely change the recurrence rate and can give false reassurance.

Should I avoid all acidic foods forever?

Try a two-week trial without the suspected item first. If sores drop by 50 % or more, reintroduce gradually to find your tolerance.

How can I tell canker sores from oral thrush?

Thrush appears as cheesy white patches that scrape off, whereas canker sores are punched-out yellow centers with red halos.

Is it normal for a canker sore to bleed?

Mild oozing after accidental biting is normal, but continuous bleeding needs a dental check the same day.

Will closing a vitamin B12 gap stop ulcers immediately?

Pain relief may begin in 7–10 days, but full prevention usually takes six to eight weeks of normalized blood levels.

Can hormonal changes trigger sores?

Yes—about 15 % of women notice flare-ups during the luteal phase; tracking your cycle can confirm the pattern.

Why does orthodontic treatment worsen the problem?

New wires and brackets create fresh friction points; silicone wax and warm-salt rinses cut ulcer days in half during adjustment weeks.

Is laser therapy an option?

CO2 or diode lasers can seal nerve endings and sterilize the area in a single visit, but they are costly and data are still limited.

This content is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider for diagnosis, treatment, and personalized medical recommendations.

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