What really causes gum disease, and how can you stop it?

By Sina Hartung, MMSC-BMI, Harvard Medical SchoolReviewed by Eureka Health Medical Group
Published: July 23, 2025Updated: July 23, 2025

Key Takeaways

Gum disease begins when oral bacteria in sticky plaque are not removed and trigger chronic inflammation of the gums. Smoking, poorly controlled diabetes, genetics, certain medications, hormonal shifts, and a dry mouth all accelerate this bacterial-driven process. Left untreated, the inflammation erodes supporting bone, loosens teeth, and raises the risk of heart and lung problems. Consistent plaque control and professional care are the only proven ways to halt progression.

What specific factors start gum disease in the first place?

Gum disease (gingivitis and periodontitis) is triggered by a mix of bacterial overgrowth and host response. Plaque bacteria produce toxins that inflame gum tissue; if the biofilm is not disrupted daily, the body’s immune response turns destructive.

  • Plaque bacteria form within 4–12 hours after brushingWhen plaque sits for more than a day it hardens into tartar, a rough surface that shelters even more bacteria.
  • Smoking multiplies periodontitis risk by 3–6 timesNicotine reduces blood flow, impairing the gums’ ability to fight infection; “tobacco smoke changes the oral microbiome towards more aggressive species,” notes the team at Eureka Health.
  • Uncontrolled diabetes doubles attachment lossHigh blood glucose fuels bacterial growth and weakens collagen, making the gums easier to invade.
  • Certain blood-pressure drugs and antihistamines dry the mouthReduced saliva removes a key natural defense; Sina Hartung, MMSC-BMI, explains: “Saliva buffers acid and washes away microbes—without it, plaque matures faster.”}]},{
  • Genetic predisposition affects up to 30 % of peopleAround one-third of the population inherits a stronger inflammatory response, making them more vulnerable to periodontal destruction even with good oral hygiene. (DrAbbo)
  • Pregnancy and menopause hormones amplify gum inflammationSurges in estrogen and progesterone increase blood flow to gums and can exaggerate tissue reactions to plaque, putting women at higher risk of gingivitis during these life stages. (Healthline)

Frequently Asked Questions

This content is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider for diagnosis, treatment, and personalized medical recommendations.

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