Why Can’t I Put on Weight Even When I Eat a Lot?

By Sina Hartung, MMSC-BMI, Harvard Medical SchoolReviewed by Eureka Health Medical Group
Published: July 9, 2025Updated: July 9, 2025

Summary

Consistently failing to gain weight despite adequate calories often means one of three things: you are burning more energy than you think, your body is not absorbing nutrients properly, or an underlying medical condition is increasing your metabolic rate. A simple weight-tracking log, basic lab work, and a review of medicines usually reveal the cause and guide fixes such as calorie-dense meals, gut treatment, or thyroid care.

Is being “naturally thin” always normal, or can it signal a problem?

About 10 % of adults struggle to maintain a body-mass index (BMI) above 18.5. A fast metabolism can be healthy, but persistent inability to gain weight may point to conditions like overactive thyroid or celiac disease. “If your weight has stayed below the 5th percentile for your age for six months, it warrants a medical work-up,” says the team at Eureka Health.

  • Metabolic rate differences can be largeResting energy expenditure varies up to 30 % between individuals; a 140-pound person may burn an extra 400 calories a day compared with peers.
  • Malabsorption blocks calorie uptakeDiseases such as celiac sprue, pancreatic insufficiency, and Crohn’s reduce fat and protein absorption, so calories leave in the stool instead of the bloodstream.
  • Medications can suppress weight gainDrugs like topiramate and some ADHD stimulants cut appetite or raise metabolism, leading to unintended weight loss despite normal meals.
  • Chronic infections burn calories quietlyTuberculosis, HIV, and hidden abscesses raise inflammatory cytokines that speed up basal metabolism by 10-15 %.
  • Rare chromosome 16 duplication keeps some adults underweightCarrying an extra copy of 28 genes on chromosome 16 affects about 1 in 2,000 people and is linked to lifelong difficulty gaining weight despite normal eating. (Cathe)
  • Constitutionally thin adults show low BMI but normal body-fat percentA study found women with constitutional thinness averaged a BMI below 17.5 yet still had 18.9 % body fat—almost double the 11.4 % seen in anorexia—while sharing similarly low muscle mass. (Nature)

Which red-flag symptoms mean being underweight is urgent?

Unexplained thinness can be a sign of serious disease when it comes with certain warning signs. “Rapid weight loss of more than 5 % body weight in a month should never be brushed off,” notes Sina Hartung, MMSC-BMI.

  • New-onset palpitations and heat intoleranceThese suggest hyperthyroidism, a condition that can lead to arrhythmias if untreated.
  • Greasy, floating stoolsSteatorrhea points toward fat malabsorption from pancreatic or small-bowel disease.
  • Persistent diarrhea or blood in stoolMay indicate inflammatory bowel disease or colorectal cancer and needs colonoscopy.
  • Night sweats and feversRaise suspicion for lymphoma or chronic infection; both demand prompt imaging and labs.
  • Loss of muscle despite high protein intakeCould signal hypercortisolism or advanced HIV, which break down muscle protein aggressively.
  • Unintentional 5–10 % weight loss within six monthsDropping this amount of body weight without trying meets clinical criteria for malnutrition and should trigger prompt medical evaluation. (HSE)
  • Lightheadedness or chest pain in a very thin patientSevere malnutrition can manifest with palpitations, dizziness, and chest pain—symptoms that demand urgent assessment to rule out cardiac compromise and electrolyte imbalance. (ACUTE)

What medical conditions most often keep weight from sticking?

Multiple organ systems influence weight. Identifying the right one shortens the path to treatment. The team at Eureka Health explains, “A targeted lab panel finds the cause in nearly 70 % of persistently underweight adults.”

  • Overactive thyroid (hyperthyroidism)Increases resting calorie burn by up to 60 %; TSH is usually below 0.4 mIU/L.
  • Undiagnosed type 1 or type 2 diabetesGlucose spills in urine; the body cannibalizes fat and muscle to compensate.
  • Celiac diseasePositive tissue-transglutaminase IgA occurs in roughly 1 % of the population and causes villous atrophy that blocks nutrient uptake.
  • Chronic obstructive pulmonary disease (COPD)Up to 25 % of COPD patients are underweight because labored breathing burns extra calories.
  • Major depressive or anxiety disordersNeurotransmitter changes can blunt appetite; 14 % of people with major depression have BMI under 18.5.
  • Cancer-related cachexia wastes body massUp to 80 % of people with advanced lung or digestive-tract cancers develop cachexia, a hyper-catabolic state that rapidly strips both muscle and fat even when meals are adequate. (CRUK)
  • Inflammatory bowel disease inflames away caloriesCrohn’s disease and ulcerative colitis drive intestinal inflammation, diarrhea and malabsorption, making IBD a leading culprit when weight refuses to stick despite normal eating. (Healthline)

How can I increase calories in a healthy way without feeling stuffed?

Calorie-dense, nutrient-rich strategies work better than simply “eating more.” Sina Hartung, MMSC-BMI advises, “Aim for 500 additional calories per day; that should translate to roughly one pound per week once medical issues are ruled out.”

  • Add liquid calories between mealsBlend 2 Tbsp peanut butter, a banana, whole-milk yogurt, and honey for a 400-calorie shake that finishes in four minutes.
  • Fortify familiar foodsStir 1 Tbsp olive oil (120 calories) into soup or pasta after cooking—taste barely changes, calories jump 25 %.
  • Schedule three alarms for snacksPeople who set reminders eat 18 % more calories daily than those who rely on hunger cues.
  • Strength-train twice weeklyResistance exercise converts extra calories into lean mass; studies show a 1.5-kg gain in 8 weeks when paired with protein shakes.
  • A handful of nuts delivers about 170 caloriesUSA Swimming notes that one small handful (about 1 oz) of mixed nuts supplies roughly 170 calories you can sprinkle on cereal, yogurt, or eat solo—an easy boost with little volume. (USA Swimming)
  • Eat mini-meals every 3–5 hoursCleveland Clinic advises planning small meals every three to five hours so you accumulate more calories across the day without the discomfort of large portions. (Cleveland Clinic)

Which lab tests and treatments do doctors use for persistent underweight?

Objective testing guides targeted therapy instead of guesswork. “We start with a comprehensive metabolic panel, thyroid panel, celiac serology, and CBC; based on results, treatment may be as simple as pancreatic enzymes or as involved as antithyroid drugs,” says the team at Eureka Health.

  • TSH and free T4Detect hyperthyroidism; treatment may include beta-blockers and, if confirmed, antithyroid medication like methimazole.
  • Tissue-transglutaminase IgAA positive result leads to a gluten-free diet that normalizes weight in 70 % of celiac patients within one year.
  • Fecal elastaseLow levels (<200 μg/g) suggest pancreatic insufficiency; prescription enzyme capsules help absorb fat and add 2-3 kg in six months.
  • HbA1c and fasting glucoseIdentify diabetes; insulin or GLP-1 adjustment stops catabolic weight loss.
  • Vitamin D and B12 levelsDeficiencies are common in malabsorption and must be corrected to support muscle building.
  • 72-hour fecal fat measurementExcretion of more than 7 g of fat per day in a 72-hour stool collection confirms steatorrhea and steers clinicians toward pancreatic enzyme replacement. (Medscape)
  • Comprehensive metabolic panel before refeedingBaseline electrolytes, renal, and hepatic indices help prevent refeeding complications; Mayo Clinic notes these labs are standard when evaluating severely underweight patients with suspected eating disorders. (Mayo)

How can Eureka’s AI doctor help me find the cause of my low weight?

Eureka’s AI doctor walks you through symptom timelines, suggests specific labs, and flags red-alert signs so you know when to see a clinician in person. “Users tell us they appreciate having a structured plan instead of random internet advice,” says Sina Hartung, MMSC-BMI.

  • Personalized intake interview in 3 minutesThe chatbot asks about appetite, stool changes, thyroid symptoms, and medications to narrow likely causes.
  • Evidence-based lab recommendationsIf your answers hint at malabsorption, the AI suggests tests like fecal fat and tTG IgA, which a human doctor on our team reviews before ordering.
  • Secure data trackingDaily weight entries form a graph that highlights plateaus or sudden drops, helping your clinician see trends at a glance.

Real-world success: gaining weight with help from Eureka’s AI doctor

Eureka is not another calorie counter. It connects insights to action. Among users who came in underweight, 67 % reached their target BMI within six months, and they rate the app 4.7 out of 5 stars for ease of use.

  • Treatment plans reviewed by physiciansAfter AI suggests a plan—say, pancreatic enzyme therapy—our medical team approves or adjusts before prescriptions are issued.
  • Automated reminders boost adherencePush notifications for snack times led to a 23 % higher calorie intake compared with those who turned reminders off.
  • Privacy-first designAll health data stays encrypted; no information is sold or shared without consent, easing fears about sensitive weight records.

Become your own doctor

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Frequently Asked Questions

Do I need to see a doctor if I feel healthy but can’t gain weight?

Yes. A simple thyroid test or celiac screen can uncover hidden conditions even when you feel fine.

What BMI is considered underweight for adults?

A BMI below 18.5 is classified as underweight for both men and women.

Can high metabolism alone stop me from gaining weight?

Yes, but true isolated high metabolism is rare; most people also underestimate calorie needs or have malabsorption.

Are weight-gain supplements like creatine safe?

Creatine is generally safe for healthy kidneys, but it will not fix medical causes of low weight. Check labs first.

How long should I try diet changes before seeking medical tests?

If you fail to add at least 1 kg after eight weeks of a 500-calorie surplus, schedule lab work.

Could parasites be the reason I’m not gaining weight?

Yes. Giardia and tapeworms can cause malabsorption; stool ova and parasite testing will identify them.

Will quitting smoking help me gain weight?

Likely. Nicotine raises resting metabolism and suppresses appetite; weight often increases 4-5 kg within a year of quitting.

Is it safe to use appetite stimulants?

Prescription stimulants like cyproheptadine can help, but they should be used only after medical evaluation and monitoring.

Does exercising burn too many calories when I’m underweight?

Endurance training can, but targeted strength training usually helps by stimulating muscle growth.

This content is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider for diagnosis, treatment, and personalized medical recommendations.